REACTIVATION OF THE TUMOUR SUPPRESSOR RASSF1A IN BREAST CANCER BY SIMULTANEOUS TARGETING OF DNA AND E2F1 METHYLATION.

Reactivation of the tumour suppressor RASSF1A in breast cancer by simultaneous targeting of DNA and E2F1 methylation.

BackgroundTumour suppressor genes are often transcriptionally silenced by promoter hypermethylation, and recent Glycerine research has implicated alterations in chromatin structure as the mechanistic basis for this repression.In addition to DNA methylation, other epigenetic post-translational modifications that modulate the stability and binding of

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Remarkable Protective Effects of Nrf2-Mediated Antioxidant Enzymes and Tissue Specificity in Different Skeletal Muscles of Daurian Ground Squirrels Over the Torpor-Arousal Cycle

Hibernating mammals experience conditions of extreme oxidative stress, such as fasting, muscle disuse, and repeated hypoxic ischemia-reperfusion, during the torpor-arousal cycle.Despite this, they experience little oxidative injury and are thus an interesting model of anti-oxidative damage.Thus, in the current study, we explored the levels and unde

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